The ABE curriculum allows students to learn about core technologies used by scientists in the discovery of human therapeutics, so that they will better understand the role of biotechnology and the potential impact of this industry on our future. The ABE curriculum should be used for educational purposes only.
The ABE labs allow students to carry out some of the important steps taken by the biotechnology industry to develop medicines to treat a variety of diseases. By engaging in this program, students will be more motivated to understand the underlying science concepts, develop critical laboratory skills, and equipped to pursue future careers in science.
If students complete the full sequence of ABE labs (which takes ~3 weeks), they will produce a recombinant DNA molecule and then use it to transform E. coli.
Note: The Teacher Guide is password-protected—please contact the ABE Program Office for access.
Nota: La Guía del Maestro está protegida por contraseña. Póngase en contacto con la Oficina del Programa ABE para obtener acceso.
ABE Non-Laboratory Materials
In this module, which has been piloted by ABE teachers, students are introduced to the concept of genes (genotypes) which code for the traits that are expressed by organisms (phenotypes). To engage students in the topic, they make an inventory of some of their own genetic traits, investigating how they are passed down and examine the genetics of some familiar organisms (such as pets).
In this module, which has been piloted by ABE teachers, students become engaged in the story of a young woman who has cystic fibrosis. After watching a video about her daily routine, they begin to develop a set of questions that they have about the disease, its treatment, and its consequences. They explore how questions can be altered from interesting to scientific. They examine real data to determine how it is inherited, experiment with osmosis to explore the disease’s possible mechanism of action, and investigate transcription and translation of actual CFTR exons. Supporting article: H Andersen, D & G Hodges. (1946). CELIAC SYNDROMEV. Genetics of Cystic Fibrosis of the Pancreas With a Consideration of Etiology. American journal of diseases of children (1911).
In this module, which is currently being reviewed by ABE teachers and Amgen scientists, students learn that genetics is more complex than the simple binary relationship it is often portrayed as having. They explore how extreme phenotypes can be used to inform our understanding of drug development and investigate some of the cutting edge techniques being used in biotechnology today, including genome wide association studies and CRISPR-Cas9.
Note: The Non-Laboratory modules are password-protected—please contact the ABE Program Office for access.
The ABE curriculum should be used for educational purposes only.